Neurotensin

Neurotensin.

Theranostic Applications of Neurotensin

Targeted theranostics is increasingly attractive in the cancer field to reduce off-target effects and provide rapid diagnosis. Neurotensin (NT) and its derivatives target neuortensin receptor 1 (NTS1) which has strong, selective, aberrant expression in certain tumour cells. This commentary briefly describes the advantages of targeting using the NT/NTS1 pairing and discusses a recent article on ...

Hyperglycemic effect of neurotensin.

Mechanisms of hyperglycemic action of neurotensin were investigated in anesthetized dogs. The intravenous administration of neurotensin 1.0 microgram/kg for 5 min induced an immediate decrease in arterial blood pressure and increases in levels of blood glucose, glucagon and insulin. Although blood levels of glucagon and insulin were greatly reduced and not elevated by neurotensin in the presenc...

Neurotensin and dopamine interactions.

Interactions between the classical monoamine neurotransmitter dopamine (DA) and the peptide neurotransmitter neurotensin (NT) in the central nervous system (CNS) have now been investigated for over two decades. Interest in this topic has been sustained, primarily because of the potential clinical relevance of these interactions to schizophrenia and drug abuse. In the past five years, important ...

The synthesis of neurotensin.

A tridecapeptide having the amino acid sequence, less than Glu-Leu-Tyr-Glu-Asn-Pro-Arg-Arg-Pro-Tyr-Iie-Leu-OH, (The nomenclature and symbols follow the suggestions of the IUPAC-IUB Commission on Biochemical Nomenclature (1972) J. Biol. Chem. 247, 977).) has been synthesized by the Merrifield solid-phase procedure. The synthetic scheme chosen involved synthesis of the peptide in the (Gln) form a...